Skin Barrier Function
Skin is the largest organ and covers the entire surface of the body. It is often damaged in disease states, such as atopic dermatitis and hypothyroidism. The epidermal barrier functions as a brick-and-mortar design of the stratum corneum, with the bricks representing corneocytes and the mortar representing the intercellular lipid complex (ceramides, free fatty acids, and cholesterol).
What are Ceramides?
Ceramides comprise 40–50% of the main lipids responsible for maintaining the cohesion of the stratum corneum, the skin lipid barrier controlling local flora (antibacterial and antifungal effects) and maintaining the correct moisture balance.¹
They are essential to maintaining the skin’s structural integrity and barrier function, which is vital in preventing moisture loss and blocking allergens.
Key Science Behind CeraGuard™
Research indicates that dogs suffering from atopic dermatitis have a reduction in ceramide levels in the skin, which may contribute to their compromised barrier function. CeraGuard™ contains a skin-identical lipid concentrate, resembling the structure of the lipid barrier in the Stratum Corneum. It contains a mix of different types of ceramides, cholesterol, free fatty
acids, and phytosphingosine, making it an ideal addition to our products, providing enhanced moisturization and unique restoring capabilities.
The Importance of Using Shampoos, Sprays, Wipes and Mousses
The International Committee of Allergic Diseases of Animals (ICADA) recommends using shampoos and mousses to help restore the skin barrier in allergic patients. Bathing is essential because it improves intercellular lipids in the epidermis and strengthens the epidermal barrier. It helps wash away pollen, dust, dander, and environmental allergens that can cling to the coat and trigger allergic reactions (e.g., atopic dermatitis).
